rs74911261

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

KDEL motif-containing protein 2 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 1.30
p 2.0e-257
N 10,708
Large GWAS
European
Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR —
β 1.310
p 1.0e-69
N 3,301
Large GWAS
European

blood protein amount

Emilsson V et al. “Co-regulatory networks of human serum proteins link genetics to disease.” Science (new York, N.y.) 361(6404):769-773 (2018)
Allele G
OR 1.61
p 1.0e-68
N 3,200
Large GWAS
European

prostate carcinoma

Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)
Allele A
OR 1.17
p 1.0e-18
N 944,762
Large GWAS
multi-ancestry
Conti DV et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics 53(1):65-75 (2021)
Allele A
OR 1.15
p 8.0e-9
N 234,253
Meta-analysisLarge GWAS
multi-ancestry

breast carcinoma

Milne RL et al. “Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.” Nature Genetics 49(12):1767-1778 (2017)
Allele G
OR 1.22
p 5.0e-11
N 87,829
Large GWAS
European

renal cell carcinoma

Scelo G et al. “Genome-wide association study identifies multiple risk loci for renal cell carcinoma.” Nature Communications 8:15724 (2017)
Allele A
OR 1.41
p 2.0e-10
N 31,190
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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