rs7525548

This is a intron variant variant in the TNNI3K gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking status measurement

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele T

OR 0.01

p 5.0e-19

N 1,359,002

Large GWAS

European

age at first sexual intercourse measurement

Mills MC et al. “Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.” Nature Human Behaviour 5(12):1717-1730 (2021)

Allele A

OR 0.01

p 3.0e-12

N 397,338

Large GWAS

European

About TNNI3K

This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]

View all TNNI3K variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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