rs7536201

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

psoriasis

Tsoi LC et al. “Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.” Nature Genetics 44(12):1341-8 (2012)
Allele C
OR 1.13
p 2.0e-12
N 33,394
Large GWAS
European
Liu S et al. “Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.” Briefings in Bioinformatics 26(1) (2024)
Allele C
OR 0.10
p 2.0e-10
N 863,080
Large GWAS
European

psoriasis vulgaris

Stuart PE et al. “Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.” American Journal of Human Genetics 97(6):816-36 (2015)
Allele C
OR 1.13
p 2.0e-8
N 8,941
Large GWAS
European
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Research that mentions this SNP (1)

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Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis
Meta-analysisN=9,794Jawed R. et al.(2020)· Immunogenetics

This replication and meta-analysis study examined the association between the RUNX3 locus and primary biliary cholangitis (PBC) in Han Chinese. The tag SNP rs7529070 showed suggestive association with PBC in a meta-analysis of 2553 cases and 7241 controls (p = 1.7 × 10⁻⁴, OR = 1.18, 95% CI = 1.08-1.28). Rs7529070 was in complete linkage disequilibrium with rs4648889, which is known to regulate RUNX3 expression. The study also demonstrated significantly increased RUNX3 expression in PBC patients compared to controls and in a PBC mouse model, suggesting increased RUNX3 expression may promote PBC pathogenesis.

Traits studied:Primary biliary cholangitisPrimary biliary cirrhosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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