rs7536458
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
vital capacity
Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)
Allele T
OR 9.24
p 2.0e-20
N 588,452
Large GWAS
multi-ancestry
smoking behavior, BMI-adjusted waist circumference
Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele T
OR —
p 7.0e-17
N 195,506
Meta-analysisLarge GWAS
multi-ancestry
infant body height
van der Valk RJ et al. “A novel common variant in DCST2 is associated with length in early life and height in adulthood.” Human Molecular Genetics 24(4):1155-68 (2015)
Allele G
OR 0.06
p 1.0e-10
N 28,238
Large GWAS
European
body mass index
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.01
p 2.0e-10
N 523,818
Large GWAS
multi-ancestry
Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)
Allele G
OR 0.01
p 6.0e-9
N 650,000
Large GWAS
European
comparative body size at age 10, self-reported
Richardson TG et al. “Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.” Bmj (clinical Research Ed.) 369:m1203 (2020)
Allele T
OR 0.01
p 2.0e-10
N 453,169
Large GWAS
European
BMI-adjusted waist circumference
Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele G
OR 0.02
p 2.0e-8
N 219,872
Major Consortium StudyLarge GWAS
European
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele G
OR 0.04
p 5.0e-10
N 160,475
Meta-analysisLarge GWAS
multi-ancestry
Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele G
OR 0.03
p 6.0e-14
N 152,914
Meta-analysisLarge GWAS
multi-ancestry
Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele G
OR 0.04
p 4.0e-12
N 143,480
Large GWAS
multi-ancestry
body height
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.07
p 5.0e-78
N 607,511
Major Consortium StudyLarge GWAS
multi-ancestry
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.04
p 3.0e-25
N 293,593
Large GWAS
African unspecified
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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