rs75418188
This is a protein-altering variant in the SLC16A11 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 2 diabetes mellitus
Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)
Allele T
OR 1.14
p 6.0e-18
N 210,865
Large GWAS
East Asian
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.13
p 2.0e-17
N 667,504
Large GWAS
multi-ancestry
Imamura M et al. “Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.” Nature Communications 7:10531 (2016)
Allele T
OR 1.20
p 8.0e-11
N 41,646
Large GWAS
multi-ancestry
Drugs used in diabetes use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.15
p 9.0e-16
N 178,726
Large GWAS
East Asian
About SLC16A11
Enables pyruvate transmembrane transporter activity. Involved in lipid metabolic process. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SLC16A11 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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