rs7554607
This variant is located in the RYR2 gene.
▶Research that mentions this SNP (1)
▶Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese populationAssociationN=1,579Songyu Cao et al.(2016)· Journal of Cancer Research and Clinical Oncology
Replication study in a Chinese population confirming associations between 16 SNPs and acute myeloid leukemia (AML) risk identified in European GWAS studies. Seven SNPs showed significant associations with AML susceptibility, including rs2191566 (OR=1.46), rs9290663 (OR=1.26), rs11155133 (OR=1.32), rs10873876 (OR=0.62, protective), rs2239633, rs10821936, and rs2242041, in a case-control study of 545 AML cases and 1034 controls.
About RYR2
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
View all RYR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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