rs755658
This is a regulatory region variant variant in the FKBP5 gene.
▶Research that mentions this SNP (1)
▶Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipientsAssociationN=1,084Gen Shinozaki et al.(2011)· Depression and Anxiety
This case-control and follow-up study examined associations of FKBP4 and FKBP5 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, depression, anxiety, and health-related quality of life in 541 SLE patients and 543 healthy controls. FKBP5 gene polymorphisms were associated with depression (rs4713904, rs9368878, rs7757037) and glucocorticoid efficacy in SLE patients. FKBP4 and FKBP5 polymorphisms were associated with improvements in health-related quality of life after treatment.
About FKBP5
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
View all FKBP5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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