rs7567833

This is a variant in the ALLC gene that changes a histidine to an arginine.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of plexin domain-containing protein 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.42

p 2.0e-144

N 47,745

Large GWAS

European

level of transcription initiation factor TFIID subunit 12 in blood serum

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele G

OR 1.09

p 9.0e-113

N 466

Small GWAS

African American or Afro-Caribbean

disintegrin and metalloproteinase domain-containing protein 11 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 0.32

p 2.0e-16

N 10,708

Large GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters2 publications

View on ClinVar →

About ALLC

Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]