rs7572857

This is a protein-altering variant in the CEP68 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Mahajan A et al. “Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.” Nature Genetics 50(4):559-571 (2018)
Allele G
OR 1.05
p 8.0e-9
N 452,244
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population
AssociationN=1,940Byung Lae Park et al.(2013)· Human Genetics

Genome-wide association study identifying HLA-DPB1 rs1042151 (Met105Val) as the most significant genetic variant associated with aspirin-exacerbated respiratory disease (AERD) in Korean asthmatics (p = 5.11 × 10−7; OR = 2.40). The variant also showed significant gene-dose effects on FEV1 decline following aspirin challenge (p = 2.82 × 10−7), confirming HLA-DPB1 as a key susceptibility locus for AERD.

Traits studied:Aspirin-exacerbated respiratory disease (AERD)AsthmaChronic rhinosinusitisFEV1 decline following aspirin challengeNasal polyps
PubMedDOIMetascience Observatory

About CEP68

Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

View all CEP68 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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