rs7573293
This variant is located in the CCDC141 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
descending aorta diameter
Pirruccello JP et al. “The Genetic Determinants of Aortic Distention.” Journal of the American College of Cardiology 81(14):1320-1335 (2023)
Allele C
OR 0.03
p 2.0e-8
N 39,893
Large GWAS
European, NR
aortic measurement
Francis CM et al. “Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities.” Nature Communications 13(1):4505 (2022)
Allele C
OR 3.33
p 3.0e-8
N 32,590
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
3 submitters2 publicationsAbout CCDC141
Predicted to be involved in brain development. Predicted to act upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Predicted to be located in centrosome and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all CCDC141 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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