rs75821091

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

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Research that mentions this SNP (1)

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A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals
AssociationN=1,283Turcot V. et al.(2012)· Human Genetics

A two-stage case-control study in 1,283 severely obese individuals identified a significant association between the IFI30 gene SNP rs11554159 (p.R76Q) and hyperglycemia/type 2 diabetes risk. Heterozygous GA individuals showed reduced risk compared to GG homozygotes (OR=0.67, P=0.0009). The protective effect was not explained by differences in IFI30 mRNA expression levels in visceral adipose tissue, suggesting a functional effect of the variant rather than an expression effect.

Traits studied:Cardiovascular disease risk factorsDyslipidemiaFasting plasma glucoseHyperglycemiaHypertensionMetabolic syndromeType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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