rs75875565

This variant is located in the ANO4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

gut microbiome measurement, breastfeeding duration

Stickley SA et al. “Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.” The Journal of Allergy and Clinical Immunology 156(2):433-448 (2025)

Allele A

OR —

β 0.050

p 4.0e-8

N 688

Small GWAS

multi-ancestry

About ANO4

Enables intracellularly calcium-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ANO4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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