rs7596872
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter hyperintensity measurement
Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)
Allele A
OR 0.10
p 4.0e-24
N 48,454
Large GWAS
European
Persyn E et al. “Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.” Nature Communications 11(1):2175 (2020)
Allele A
OR 9.13
p 2.0e-20
N 45,204
Large GWAS
multi-ancestry
Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele A
OR 8.80
p 1.0e-18
N 30,708
Large GWAS
European
Armstrong NJ et al. “Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.” Stroke 51(7):2111-2121 (2020)
Allele A
OR 0.06
p 9.0e-11
N 18,226
Large GWAS
multi-ancestry
Traylor M et al. “Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).” Neurology 92(8):e749-e757 (2019)
Allele A
OR 0.14
p 3.0e-12
N 11,226
Large GWAS
European
Inguinal hernia
Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.15
p 3.0e-15
N 275,546
Major Consortium StudyLarge GWAS
European
perivascular space measurement
Duperron MG et al. “Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.” Nature Medicine 29(4):950-962 (2023)
Allele C
OR —
p 1.0e-10
N 38,598
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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