rs7604288
This variant is located in the MAP3K20 gene.
▶Research that mentions this SNP (1)
▶Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancerMeta-analysisN=14,463Yun Feng et al.(2018)· Molecular Carcinogenesis
A pathway-based genome-wide association study meta-analysis of 8 GWAS cohorts (12,160–14,463 cases, 16,838–43,365 controls) investigating P38MAPK pathway genes and lung cancer risk. Two significant SNPs in ZAK (rs3769201 and rs722864) were associated with decreased lung cancer risk (OR ~0.86–0.88) and decreased ZAK mRNA expression levels.
About MAP3K20
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
View all MAP3K20 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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