rs7612445

This is a upstream gene variant variant in the GNB4 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)

Allele T

OR 0.05

p 4.0e-31

N 2,584,013

Large GWAS

multi-ancestry

Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)

Allele T

OR 0.05

p 9.0e-13

N 2,339,188

Large GWAS

multi-ancestry

Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)

Allele T

OR 1.05

p 7.0e-21

N 1,650,345

Meta-analysisLarge GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.01

p 7.0e-9

N 1,486,094

Large GWAS

European

Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)

Allele T

OR 1.05

p 5.0e-9

N 1,030,836

Large GWAS

European

heart rate

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.04

p 3.0e-31

N 425,720

Major Consortium StudyLarge GWAS

European

Eppinga RN et al. “Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.” Nature Genetics 48(12):1557-1563 (2016)

Allele G

OR 0.43

p 2.0e-24

N 134,251

Large GWAS

multi-ancestry

den Hoed M et al. “Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.” Nature Genetics 45(6):621-31 (2013)

Allele G

OR 0.36

p 2.0e-14

N 92,355

Large GWAS

multi-ancestry

heart rate variability measurement

Tegegne BS et al. “Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality.” Communications Biology 6(1):1013 (2023)

Allele G

OR 0.80

p 2.0e-8

N 46,075

Large GWAS

European

About GNB4

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]

rs7612445

GWAS Catalog Trait Associations (3)

atrial fibrillation

heart rate

heart rate variability measurement

About GNB4

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