rs762061316

This variant is located in the KLF5 gene.

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ClinVar annotation

Uncertain Significance★☆☆☆

1 submitter

not specified

About KLF5

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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