rs76299266
This variant is located in the GRHPR gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of glyoxylate reductase/hydroxypyruvate reductase in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.33
p 2.0e-12
N 47,745
Large GWAS
European
▶ClinVar annotation
Likely Benign★★★☆
8 submitters2 publicationsnot provided; not specified; Primary hyperoxaluria, type II
View on ClinVar →About GRHPR
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
View all GRHPR variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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