rs7638750
This is a regulatory region variant variant in the TCTA gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
smoking initiation
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 3.0e-24
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
smoking cessation
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele T
OR 0.01
p 2.0e-17
N 820,192
Large GWAS
European
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 1.0e-15
N 1,400,535
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
About TCTA
Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all TCTA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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