rs76502631

This is a regulatory region variant variant in the NIT1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of deaminated glutathione amidase in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.62

p 5.0e-256

N 47,745

Large GWAS

European

protein measurement

He B et al. “Genome-wide pQTL analysis of protein expression regulatory networks in the human liver.” Bmc Biology 18(1):97 (2020)

Allele A

OR —

β 0.043

p 5.0e-10

N 287

Small GWAS

multi-ancestry

About NIT1

This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

View all NIT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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