rs7650482

This is a intron variant variant in the CAND2 gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele A
OR 0.03
p 1.0e-16
N 2,358,556
Large GWAS
multi-ancestry
Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)
Allele A
OR 0.03
p 7.0e-9
N 1,672,415
Large GWAS
multi-ancestry

repulsive guidance molecule A measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 8.0e-14
N 47,745
Large GWAS
European

electrocardiography

Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele A
OR 0.04
p 1.0e-13
N 63,706
Major Consortium StudyLarge GWAS
European, NR

cardiac troponin I measurement

Moksnes MR et al. “Genome-wide association study of cardiac troponin I in the general population.” Human Molecular Genetics 30(21):2027-2039 (2021)
Allele G
OR 0.04
p 4.0e-10
N 48,115
Large GWAS
European

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)
Allele A
OR —
p 4.0e-10
N 2,535,601
Large GWAS
multi-ancestry

glucose measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.01
p 5.0e-9
N 448,252
Large GWAS
multi-ancestry

atrial fibrillation

Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)
Allele A
OR 0.08
p 5.0e-35
N 2,339,188
Large GWAS
multi-ancestry
Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele A
OR 0.07
p 2.0e-95
N 1,840,341
Large GWAS
European
Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)
Allele A
OR 1.08
p 7.0e-72
N 1,650,345
Meta-analysisLarge GWAS
multi-ancestry
Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)
Allele A
OR 1.07
p 2.0e-24
N 1,030,836
Large GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.08
p 9.0e-17
N 589,441
Large GWAS
multi-ancestry
Roselli C et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nature Genetics 50(9):1225-1233 (2018)
Allele A
OR 1.08
p 4.0e-22
N 588,190
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.07
p 3.0e-40
N 437,772
Major Consortium StudyLarge GWAS
European

cardiomyopathy

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.08
p 4.0e-15
N 439,014
Major Consortium StudyLarge GWAS
European

About CAND2

Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of DNA-templated transcription; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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