rs7659024

This is a downstream gene variant variant.

▶

GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

deep vein thrombosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.22

p 2.0e-78

N 623,167

Major Consortium StudyLarge GWAS

multi-ancestry

drug use measurement, deep vein thrombosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.17

p 8.0e-25

N 400,487

Major Consortium StudyLarge GWAS

multi-ancestry

venous thromboembolism

Germain M et al. “Genetics of venous thrombosis: insights from a new genome wide association study.” Plos One 6(9):e25581 (2011)

Allele A

OR 1.53

p 2.0e-13

N 2,652

Large GWAS

European

▶

Research that mentions this SNP (1)

▶

A Genome‐Wide Association Study for Venous Thromboembolism: The Extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

AssociationN=11,615Weihong Tang et al.(2013)· Genetic Epidemiology

A large genome-wide association study of venous thromboembolism (VTE) in 9 European ancestry cohorts (4,849 cases total) identified genome-wide significant associations at F5, ABO, F11, and FGG loci. The FGG locus (rs6536024, RR=0.80, p<5.0×10⁻¹³) and F11 locus (rs4253399, RR=1.24, p<5.0×10⁻¹³) showed novel associations with reduced and increased VTE risk respectively. Additional borderline associations (p<5.0×10⁻⁶) were identified near SUSD1 and OTUD7A, representing new candidate genes for VTE.

Traits studied:Deep venous thrombosisPulmonary embolismVenous thromboembolism

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.