rs76608582

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking behavior trait

Wootton RE et al. “Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.” Psychological Medicine 50(14):2435-2443 (2020)
Allele C
OR 0.03
p 3.0e-10
N 462,690
Large GWAS
European

smoking status measurement

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele A
OR 0.03
p 5.0e-9
N 1,232,091
Large GWAS
European
Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)
Allele A
OR 0.03
p 3.0e-8
N 283,749
Major Consortium StudyLarge GWAS
European

smoking initiation

Erzurumluoglu AM et al. “Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.” Molecular Psychiatry 25(10):2392-2409 (2020)
Allele A
OR 0.04
p 9.0e-9
N 346,813
Meta-analysisLarge GWAS
multi-ancestry
Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele A
OR 0.03
p 1.0e-8
N 433,216
Meta-analysisLarge GWAS
European

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 5.57
p 3.0e-8
N 269,867
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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