rs76774446
This variant is located in the GOSR2 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
right ventricular diastolic volume measurement
Aung N et al. “Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.” Nature Genetics 54(6):783-791 (2022)
Allele C
OR 0.07
p 2.0e-16
N 29,506
Large GWAS
European
cardioembolic stroke
Cárcel-Márquez J et al. “A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.” Frontiers in Cardiovascular Medicine 9:940696 (2022)
Allele A
OR 6.63
p 3.0e-11
N 362,661
Large GWAS
European
Mishra A et al. “Stroke genetics informs drug discovery and risk prediction across ancestries.” Nature 611(7934):115-123 (2022)
Allele A
OR 1.09
p 8.0e-11
N 1,245,612
Large GWAS
European
atrial fibrillation
Roselli C et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nature Genetics 50(9):1225-1233 (2018)
Allele A
OR 1.07
p 1.0e-8
N 588,190
Large GWAS
multi-ancestry
About GOSR2
This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]
View all GOSR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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