rs769409347
This variant is located in the ORC4 gene.
▶ClinVar annotation
not specified; ORC4-related disorder; not provided
View on ClinVar →About ORC4
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
View all ORC4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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