rs7726839
This is a intron variant variant in the CEP72 gene.
▶Research that mentions this SNP (1)
▶Evidence of epistasis between TNFRSF14 and TNFRSF6B polymorphisms in patients with rheumatoid arthritisAssociationN=3,394Nieves Perdigones et al.(2010)· Arthritis & Rheumatism
This case-control study of 1,744 RA patients and 1,650 Spanish controls attempted to replicate previously reported gene-gene interactions with PTPN22 rs2476601 and GSTM1 in rheumatoid arthritis susceptibility. The study failed to replicate any of the reported interactions despite adequate statistical power and multiple testing approaches. Only PTPN22 rs2476601 showed significant association with RA (OR 1.53, 95% CI 1.29-1.80, P=4.61×10⁻⁷), but epistatic interactions with six SNPs and the GSTM1-shared epitope interaction were not confirmed.
About CEP72
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
View all CEP72 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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