rs77331626

This variant is located in the ANO8 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

rheumatoid arthritis

Okada Y et al. “Genetics of rheumatoid arthritis contributes to biology and drug discovery.” Nature 506(7488):376-381 (2014)

Allele G

OR 1.21

p 7.0e-24

N 79,799

Large GWAS

multi-ancestry

About ANO8

Enables intracellularly calcium-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ANO8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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