rs7738206

This is a upstream gene variant variant in the RPS6KA2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

plasminogen activator inhibitor 1 measurement

McCartney DL et al. “Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.” Genome Biology 22(1):194 (2021)

Allele T

OR 387.53

p 1.0e-10

N 6,149

Large GWAS

African American or Afro-Caribbean

About RPS6KA2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

View all RPS6KA2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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