rs773857
This is a downstream gene variant variant in the CPAMD8 gene.
▶Research that mentions this SNP (1)
▶Polymorphism in the protease‐activated receptor‐4 gene region associates with platelet activation and perioperative myocardial injuryAssociationN=934Jochen D. Muehlschlegel et al.(2012)· American Journal of Hematology
A genetic association study identified SNP rs773857 in the F2RL3 gene region as associated with perioperative myocardial injury (PMI) in 934 CABG surgery patients (OR 2.4, p=0.004). Risk allele homozygotes showed increased platelet counts and enhanced P-selectin release upon PAR4 activation, indicating increased platelet reactivity and α-granule degranulation.
About CPAMD8
This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]
View all CPAMD8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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