rs773902

This is a variant in the F2RL3 gene that changes a alanine to an threonine.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet reactivity efficacy

Downes K et al. “G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.” Blood Advances 6(7):2319-2330 (2022)

Allele A

OR 0.52

p 2.0e-13

N 550

Small GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters1 publication

View on ClinVar →

About F2RL3

This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

View all F2RL3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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