rs7741164

This is a intron variant variant in the FOXP4-AS1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lung adenocarcinoma

Dai J et al. “Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.” The Lancet. Respiratory Medicine 7(10):881-891 (2019)

Allele A

OR 1.19

p 7.0e-14

N 42,936

Large GWAS

multi-ancestry

Qin N et al. “Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.” Frontiers of Medicine 15(2):275-291 (2021)

Allele A

OR 1.17

p 4.0e-12

N 42,936

Large GWAS

East Asian, European

Wang Z et al. “Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.” Human Molecular Genetics 25(3):620-9 (2016)

Allele A

OR 1.18

p 1.0e-12

N 13,154

Meta-analysisLarge GWAS

East Asian

lung carcinoma

Wang Z et al. “Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.” Human Molecular Genetics 25(3):620-9 (2016)

Allele A

OR 1.17

p 6.0e-13

N 13,154

Meta-analysisLarge GWAS

East Asian

non-small cell lung carcinoma

Dai J et al. “Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.” The Lancet. Respiratory Medicine 7(10):881-891 (2019)

Allele A

OR 1.16

p 4.0e-12

N 54,475

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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