rs7746553

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

complement factor B measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele G
OR 0.30
p 4.0e-14
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

glycoprotein measurement

Yuan F et al. “Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.” British Journal of Cancer 133(1):94-103 (2025)
Allele G
OR 0.02
p 2.0e-8
N 199,732
Large GWAS
European

age at first sexual intercourse measurement

Mills MC et al. “Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.” Nature Human Behaviour 5(12):1717-1730 (2021)
Allele C
OR 0.02
p 5.0e-8
N 397,338
Large GWAS
European
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Research that mentions this SNP (1)

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Polymorphisms in complement system genes and risk of non‐Hodgkin lymphoma
AssociationN=926Bryan A. Bassig et al.(2012)· Environmental and Molecular Mutagenesis

This case-control study of 432 cases and 494 controls examined polymorphisms in complement system genes and risk of non-Hodgkin lymphoma (NHL). A significant association was found with C1RL rs3813729 (C>T), which decreased NHL risk (OR=0.60, 95% CI=0.42-0.87, P=0.0062) and DLBCL risk (OR=0.39, 95% CI=0.20-0.73, P=0.0034). Additional associations were found with C1QG rs12756603 for CLL/SLL, and C2 rs497309 and C3 rs344550 for marginal zone lymphoma, though these were based on small case numbers.

Traits studied:Chronic lymphocytic leukemia/small lymphocytic lymphomaDiffuse large B-cell lymphomaFollicular lymphomaMarginal zone lymphomaNon-Hodgkin lymphoma
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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