rs7753012
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
FEV/FVC ratio
Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)
Allele T
OR 30.58
p 2.0e-205
N 588,452
Large GWAS
multi-ancestry
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.07
p 5.0e-165
N 321,047
Large GWAS
European
Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)
Allele T
OR 0.08
p 2.0e-31
N 48,943
Large GWAS
European
chronic obstructive pulmonary disease
Cosentino J et al. “Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.” Nature Genetics 55(5):787-795 (2023)
Allele T
OR 0.05
p 3.0e-110
N 325,027
Large GWAS
European
Kim W et al. “Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.” American Journal of Epidemiology 190(5):875-885 (2021)
Allele T
OR 0.85
p 4.0e-20
N 200,766
Large GWAS
European
Joo J et al. “Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD.” Amia ... Annual Symposium Proceedings. Amia Symposium 2021:601-610 (2021)
Allele T
OR 0.86
p 2.0e-22
N 108,589
Large GWAS
European
peak expiratory flow
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.04
p 3.0e-43
N 321,047
Large GWAS
European
forced expiratory volume
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.03
p 7.0e-23
N 321,047
Large GWAS
European
Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)
Allele T
OR 0.05
p 2.0e-10
N 48,943
Large GWAS
European
body height
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.05
p 5.0e-17
N 77,890
Large GWAS
South Asian
Nagy R et al. “Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.” Genome Medicine 9(1):23 (2017)
Allele T
OR 0.01
p 8.0e-14
N 26,828
Major Consortium StudyLarge GWAS
European
forced expiratory volume, 25-hydroxyvitamin D3 measurement
Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)
Allele G
OR —
p 3.0e-11
N 115,312
Meta-analysisLarge GWAS
multi-ancestry
smoking status measurement, chronic obstructive pulmonary disease
Kim W et al. “Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.” American Journal of Epidemiology 190(5):875-885 (2021)
Allele G
OR —
p 2.0e-31
N 200,766
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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