rs7758229

This variant is located in the SLC22A3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Berndt SI et al. “Two susceptibility loci identified for prostate cancer aggressiveness.” Nature Communications 6:6889 (2015)

Allele T

OR 1.15

p 4.0e-12

N 7,541

Large GWAS

European

colorectal cancer

Cui R et al. “Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.” Gut 60(6):799-805 (2011)

Allele T

OR 1.28

p 8.0e-9

N 3,481

Large GWAS

East Asian

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Research that mentions this SNP (1)

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Genome‐wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians

AssociationN=19,179Ben Zhang et al.(2014)· International Journal of Cancer

A two-stage genome-wide association study (GWAS) in 19,179 East Asian individuals identified rs7229639 in the SMAD7 gene as a new colorectal cancer (CRC) risk variant with odds ratio (OR) = 1.22 (95% CI: 1.15-1.29, P = 2.93×10^-11). This novel variant is independent of previously reported CRC risk variants (rs4939827, rs58920878, rs12953717, rs4464148) in this region and explains approximately 0.75% of familial CRC risk in East Asians.

Traits studied:Colorectal cancer

PubMed DOI Metascience Observatory

About SLC22A3

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]