rs778880121

This variant is located in the H1-0 gene.

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ClinVar annotation

Uncertain Significance★☆☆☆

1 submitter

not specified

About H1-0

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

View all H1-0 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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