rs77956314

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hippocampal volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 123.31

p 2.0e-35

N 21,297

Large GWAS

European

Hibar DP et al. “Novel genetic loci associated with hippocampal volume.” Nature Communications 8:13624 (2017)

Allele C

OR 10.42

p 2.0e-25

N 26,814

Large GWAS

multi-ancestry

Klein M et al. “Genetic Markers of ADHD-Related Variations in Intracranial Volume.” The American Journal of Psychiatry 176(3):228-238 (2019)

Allele C

OR 9.53

p 2.0e-21

N 24,704

Large GWAS

European

hippocampal CA1 volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 24.08

p 7.0e-28

N 21,297

Large GWAS

European

granule cell layer dentate gyrus volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 11.01

p 9.0e-26

N 21,297

Large GWAS

European

hippocampus molecular layer volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 19.27

p 2.0e-25

N 21,297

Large GWAS

European

hippocampal CA4 volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 9.26

p 2.0e-24

N 21,297

Large GWAS

European

hippocampal formation volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 20.52

p 2.0e-19

N 21,297

Large GWAS

European

subiculum volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 12.96

p 1.0e-17

N 21,297

Large GWAS

European

hippocampal CA3 volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 7.79

p 2.0e-15

N 21,297

Large GWAS

European

brain volume, hippocampal volume

Hibar DP et al. “Common genetic variants influence human subcortical brain structures.” Nature 520(7546):224-9 (2015)

Allele T

OR 55.18

p 3.0e-15

N 13,171

Large GWAS

multi-ancestry

hippocampal amigdala transition area volume

van der Meer D et al. “Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.” Molecular Psychiatry 25(11):3053-3065 (2020)

Allele C

OR 2.04

p 4.0e-13

N 21,297

Large GWAS

European

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Research that mentions this SNP (1)

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The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels

MethodsN=30,717Brit-Maren M. Schjeide et al.(2011)· Archives of General Psychiatry

This paper presents a novel bioinformatics method combining Gene Ontology (GO) with stratified false discovery rate (sFDR) analysis to prioritize genes for imaging genetics studies. Applied to ENIGMA2 GWAS meta-analysis data of hippocampal volume (N=30,717 individuals, 6,570,616 SNPs), the transport system gene network identified SNPs with sFDR q-values between 10-20%, including rs117831534 and rs118025365 in TESC (p=4.91e-07 and 4e-07), and multiple SNPs in SLC4A10 and KCNH7. The method demonstrates improved statistical power for discovering imaging genetic biomarkers without excessive multiple testing burden.

Traits studied:Alzheimer's diseaseHippocampal volume

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs77956314

GWAS Catalog Trait Associations (11)

hippocampal volume

hippocampal CA1 volume

granule cell layer dentate gyrus volume

hippocampus molecular layer volume

hippocampal CA4 volume

hippocampal formation volume

subiculum volume

hippocampal CA3 volume

brain volume, hippocampal volume

hippocampal amigdala transition area volume

Research that mentions this SNP (1)

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