rs7816475

This is a regulatory region variant variant in the CCAT1 gene.

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Research that mentions this SNP (1)

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Common genetic variants in the 8q24 region and risk of papillary thyroid cancer
AssociationN=796Gila Neta et al.(2012)· The Laryngoscope

This case-control study evaluated 157 tag SNPs in the 8q24 chromosomal region in relation to papillary thyroid cancer (PTC) risk using 344 PTC cases and 452 controls. While previously cancer-associated SNPs (rs1562430, rs1447295, rs6983267) showed no significant association with PTC, one SNP (rs4733616, P=0.003) and 12 others showed uncorrected P<0.05 associations; however, none remained significant after false discovery rate correction, suggesting no strong association between 8q24 variants and sporadic PTC risk.

Traits studied:Bladder cancerBreast cancerChronic lymphocytic leukemiaColorectal cancerPapillary thyroid cancerProstate cancerUrinary cancer
PubMedDOIMetascience Observatory

About CCAT1

This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus. This RNA may also function as a molecular sponge for microRNAs. [provided by RefSeq, Dec 2017]

View all CCAT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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