rs7843128

This is a coding sequence variant variant in the CCAR2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Tinnitus

Clifford RE et al. “Genetic architecture distinguishes tinnitus from hearing loss.” Nature Communications 15(1):614 (2024)
Allele T
OR 5.66
p 2.0e-8
N 596,905
Large GWAS
multi-ancestry

About CCAR2

Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; regulation of primary metabolic process; and regulation of signal transduction. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Jul 2025]

View all CCAR2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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