rs7853181

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele G
OR 0.01
p 5.0e-18
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
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Research that mentions this SNP (1)

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Follow‐up association studies of chromosome region 9q and nonsyndromic cleft lip/palate
AssociationN=291Ariadne Letra et al.(2010)· American Journal of Medical Genetics Part A

Fine mapping study of 50 SNPs across chromosome 9q22.3-34.1 in 291 multiplex families from multiple populations identified association with nonsyndromic cleft lip/palate, primarily with STOM (rs306796; P=0.004 in Guatemala, P=0.002 in pooled families, P=0.04 in US). SNPs in PTCH and nearby FOXE1 also showed association, with gene prioritization analysis ranking PTCH and STOM among the top 14 candidate genes in this region.

Traits studied:Cleft lip and palate (CLCLP)Cleft lip only (CLO)Nonsyndromic cleft lip/palate
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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