rs7859886

This is a downstream gene variant variant in the MTAP gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lung adenocarcinoma

Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)

Allele A

OR 0.86

p 9.0e-19

N 143,595

Large GWAS

multi-ancestry

About MTAP

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]

View all MTAP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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