rs78857879
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter hyperintensity measurement
Sargurupremraj M et al. “Cerebral small vessel disease genomics and its implications across the lifespan.” Nature Communications 11(1):6285 (2020)
Allele A
OR 0.10
p 3.0e-22
N 50,970
Large GWAS
multi-ancestry
Verhaaren BF et al. “Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.” Circulation. Cardiovascular Genetics 8(2):398-409 (2015)
Allele A
OR —
p 2.0e-8
N 21,079
Large GWAS
multi-ancestry
refractive error
Han X et al. “Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study.” Jama Ophthalmology 138(6):671-678 (2020)
Allele G
OR 0.15
p 2.0e-15
N 95,827
Major Consortium StudyLarge GWAS
European
Inguinal hernia
Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.15
p 3.0e-15
N 275,546
Major Consortium StudyLarge GWAS
European
cerebral small vessel disease
Mishra A et al. “Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.” Brain : a Journal of Neurology 145(6):1992-2007 (2022)
Allele A
OR 1.43
p 1.0e-13
N 19,721
Large GWAS
European
perivascular space measurement
Duperron MG et al. “Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.” Nature Medicine 29(4):950-962 (2023)
Allele G
OR —
p 8.0e-11
N 38,871
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…