rs78943174
This is a intron variant variant in the NAALADL2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cancer aggressiveness measurement, Gleason score measurement, prostate carcinoma
▶Research that mentions this SNP (1)
▶Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21AssociationN=3,893Teerlink CC et al.(2016)· Human Genetics
This genome-wide association study of 2511 familial prostate cancer cases and 1382 controls identified significant associations in six regions previously linked to prostate cancer risk. Most notably, rs138042437 at 8q24.21 achieved an exceptionally large effect size (OR=13.3, p=1.7e-8) and demonstrated strong co-segregation with disease in 116 affected relatives (p=8.5e-11). The study identified a rare segregating haplotype at 8q24.21 containing three SNPs (rs183373024, rs188140481, rs138042437) that characterized a prostate cancer predisposition locus.
About NAALADL2
Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all NAALADL2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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