rs7894407
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter hyperintensity measurement
Verhaaren BF et al. “Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.” Circulation. Cardiovascular Genetics 8(2):398-409 (2015)
Allele T
OR —
p 3.0e-8
N 21,079
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶Genome‐wide association studies of cerebral white matter lesion burdenMeta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology
Genome‐wide association studies of cerebral white matter lesion burden
Meta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology
Genome-wide meta-analysis of 9,361 Europeans identified six genome-wide significant SNPs on chromosome 17q25 associated with white matter hyperintensity (WMH) burden. The most significant SNP, rs3744028 (P = 4.0×10⁻⁹ discovery, P = 1.3×10⁻⁷ replication, P = 4.0×10⁻¹⁵ combined), and rs1055129 were replicated in 3,024 additional individuals. Risk alleles increased WMH burden by 4-8% of mean burden.
Traits studied:Cerebral white matter lesionsWhite matter hyperintensities (WMH) burden
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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