rs7924176

This is a intron variant variant in the ADK gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.03
p 2.0e-26
N 424,231
Major Consortium StudyLarge GWAS
European

tooth eruption

Geller F et al. “Genome-wide association study identifies four loci associated with eruption of permanent teeth.” Plos Genetics 7(9):e1002275 (2011)
Allele A
OR 0.10
p 6.0e-18
N 5,088
Large GWAS
European
Fatemifar G et al. “Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.” Human Molecular Genetics 22(18):3807-17 (2013)
Allele A
OR 0.17
p 2.0e-8
N 11,118
Large GWAS
European

number of teeth

Grgic O et al. “Novel Genetic Determinants of Dental Maturation in Children.” Journal of Dental Research 102(3):349-356 (2023)
Allele A
OR 8.40
p 4.0e-17
N 14,805
Large GWAS
European, NR

odontogenesis

Fatemifar G et al. “Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.” Human Molecular Genetics 22(18):3807-17 (2013)
Allele A
OR 0.19
p 8.0e-16
N 11,513
Large GWAS
European

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.02
p 1.0e-17
N 425,537
Major Consortium StudyLarge GWAS
European

About ADK

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

View all ADK variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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