rs7924522

This variant is located in the ETS1 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

open-angle glaucoma

Han X et al. “Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.” Nature Genetics 55(7):1116-1125 (2023)

Allele A

OR 0.09

p 3.0e-25

N 432,017

Large GWAS

multi-ancestry

Gharahkhani P et al. “Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.” Nature Communications 12(1):1258 (2021)

Allele A

OR —

β 0.057

p 2.0e-14

N 383,500

Meta-analysisLarge GWAS

multi-ancestry

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)

Allele A

OR 0.09

p 5.0e-17

N 472,819

Meta-analysisLarge GWAS

multi-ancestry

glaucoma

Craig JE et al. “Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.” Nature Genetics 52(2):160-166 (2020)

Allele A

OR 1.10

p 7.0e-17

N 351,696

Large GWAS

European

MacGregor S et al. “Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.” Nature Genetics 50(8):1067-1071 (2018)

Allele A

OR 1.09

p 3.0e-8

N 137,086

Large GWAS

European

intraocular pressure measurement

Khawaja AP et al. “Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.” Nature Genetics 50(6):778-782 (2018)

Allele C

OR 0.11

p 3.0e-16

N 139,555

Large GWAS

European

Craig JE et al. “Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.” Nature Genetics 52(2):160-166 (2020)

Allele C

OR —

p 3.0e-15

N 133,492

Large GWAS

European

Gao XR et al. “Genome-wide association analyses identify new loci influencing intraocular pressure.” Human Molecular Genetics 27(12):2205-2213 (2018)

Allele C

OR 0.12

p 1.0e-15

N 115,486

Large GWAS

European

Han X et al. “Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study.” Jama Ophthalmology 138(6):671-678 (2020)

Allele C

OR 0.12

p 2.0e-14

N 101,939

Major Consortium StudyLarge GWAS

European

lymphocyte count

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele C

OR —

p 8.0e-11

N 234,778

Large GWAS

European

About ETS1

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

rs7924522

GWAS Catalog Trait Associations (5)

open-angle glaucoma

psoriasis

glaucoma

intraocular pressure measurement

lymphocyte count

About ETS1

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