rs7937

This is a downstream gene variant variant in the RAB4B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to aromatase inhibitor

Hertz DL et al. “Genome-wide association study of letrozole plasma concentrations identifies non-exonic variants that may affect CYP2A6 metabolic activity.” Pharmacogenetics and Genomics 31(5):116-123 (2021)

Allele G

OR 4.64

p 2.0e-9

N 228

Small GWAS

European

chronic obstructive pulmonary disease

Mathur R et al. “GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing.” Communications Biology 5(1):806 (2022)

Allele C

OR 0.74

p 2.0e-8

N 10,461

Large GWAS

multi-ancestry

About RAB4B

Enables GTPase activity. Involved in D-glucose import; early endosome to Golgi transport; and endosomal vesicle fusion. Located in insulin-responsive compartment; perinuclear region of cytoplasm; and recycling endosome. Is active in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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