rs79412431

This is a intron variant variant in the MAPT-AS1 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

forced expiratory volume

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele A

OR 0.04

p 3.0e-49

N 321,047

Large GWAS

European

vital capacity

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele A

OR 0.04

p 3.0e-46

N 321,047

Large GWAS

European

peak expiratory flow

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele A

OR 0.02

p 6.0e-15

N 321,047

Large GWAS

European

forced expiratory volume, 25-hydroxyvitamin D3 measurement

Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)

Allele G

OR —

p 9.0e-14

N 95,952

Meta-analysisLarge GWAS

multi-ancestry

About MAPT-AS1

Involved in regulatory ncRNA-mediated gene silencing. Implicated in Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]

View all MAPT-AS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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