rs7960611

This is a intron variant variant in the CLEC1A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systemic lupus erythematosus, COVID-19

Wang Y et al. “COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection.” Plos Genetics 18(11):e1010253 (2022)

Allele G

OR 1.14

p 8.0e-9

N 1,371,159

Large GWAS

European

About CLEC1A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

View all CLEC1A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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