rs7968682

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

health trait

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele G
OR 0.03
p 8.0e-142
N 405,979
Large GWAS
European

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.06
p 4.0e-78
N 288,216
Major Consortium StudyLarge GWAS
European

birth weight

Warrington NM et al. “Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.” Nature Genetics 51(5):804-814 (2019)
Allele G
OR 0.04
p 4.0e-60
N 321,223
Large GWAS
multi-ancestry
Plotnikov D et al. “Association between birth weight and refractive error in adulthood: a Mendelian randomisation study.” The British Journal of Ophthalmology 104(2):214-219 (2020)
Allele G
OR 0.04
p 7.0e-37
N 188,039
Large GWAS
European

type 2 diabetes mellitus

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele T
OR 0.05
p 7.0e-18
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.02
p 1.0e-11
N 607,391
Major Consortium StudyLarge GWAS
multi-ancestry

body height

Carty CL et al. “Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).” Human Molecular Genetics 21(3):711-20 (2012)
Allele T
OR 0.04
p 4.0e-10
N 8,149
CohortLarge GWAS
African American or Afro-Caribbean
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Research that mentions this SNP (1)

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Uterine leiomyomata and decreased height: a common HMGA2 predisposition allele
AssociationN=248Jennelle C. Hodge et al.(2009)· Human Genetics

This family-based candidate gene study identified a TC227 dinucleotide repeat (27 TC repeats) in the 5' UTR of HMGA2 significantly associated with uterine leiomyomata predisposition (p = 0.00005) and decreased height (p = 0.0021) in 248 White sister-pair families. TC227-positive women were on average 1.5 cm shorter than non-carriers. Expression analysis showed a trend toward higher HMGA2 expression in fibroid tissue from TC227 carriers, and the authors propose TC227 may influence both phenotypes through effects on age of menarche.

Traits studied:Age of menarcheHeightUterine leiomyomata
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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