rs79687284

This is a regulatory region variant variant in the PROX1-AS1 gene.

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glutamine measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.16

p 4.0e-43

N 114,751

Large GWAS

European

Abar L et al. “Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.” Nar Genomics and Bioinformatics 6(2):lqae046 (2024)

Allele G

OR 0.15

p 9.0e-43

N 117,944

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele G

OR 0.16

p 2.0e-36

N 88,070

Large GWAS

European

Lotta LA et al. “A cross-platform approach identifies genetic regulators of human metabolism and health.” Nature Genetics 53(1):54-64 (2021)

Allele G

OR 8.07

p 7.0e-16

N 85,821

Large GWAS

European

glucose measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.07

p 5.0e-36

N 394,642

Large GWAS

European

Lagou V et al. “GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.” Nature Genetics 55(9):1448-1461 (2023)

Allele C

OR 0.01

p 2.0e-26

N 475,416

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.08

p 1.0e-33

N 448,252

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.07

p 2.0e-10

N 114,870

Large GWAS

European

alanine measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.14

p 2.0e-34

N 115,078

Large GWAS

European

Abar L et al. “Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.” Nar Genomics and Bioinformatics 6(2):lqae046 (2024)

Allele G

OR 0.13

p 2.0e-31

N 117,944

Large GWAS

European

Allele G

OR 0.14

p 1.0e-33

N 88,325

Large GWAS

European

type 2 diabetes mellitus

Huerta-Chagoya A et al. “Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.” Nature Genetics 56(11):2370-2379 (2024)

Allele G

OR 0.25

p 2.0e-30

N 421,743

Large GWAS

multi-ancestry

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele G

OR 1.16

p 3.0e-16

N 898,130

Large GWAS

European

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele G

OR 0.15

p 2.0e-16

N 251,740

Large GWAS

European

tyrosine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.06

p 3.0e-27

N 450,015

Large GWAS

multi-ancestry

serum albumin amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.06

p 8.0e-20

N 928,679

Large GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 5.0e-15

N 450,015

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.05

p 4.0e-13

N 435,807

Large GWAS

multi-ancestry

leucine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 6.0e-14

N 450,015

Large GWAS

multi-ancestry

glycine measurement

Abar L et al. “Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.” Nar Genomics and Bioinformatics 6(2):lqae046 (2024)

Allele G

OR 0.06

p 1.0e-10

N 117,944

Large GWAS

European

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.07

p 2.0e-10

N 114,978

Large GWAS

European

Allele G

OR 0.08

p 2.0e-10

N 88,258

Large GWAS

European

Drugs used in diabetes use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele C

OR 0.20

p 3.0e-10

N 305,913

Major Consortium StudyLarge GWAS

European

blood glucose amount

Nagy R et al. “Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.” Genome Medicine 9(1):23 (2017)

Allele C

OR 0.20

p 2.0e-8

N 29,900

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs79687284

GWAS Catalog Trait Associations (11)

glutamine measurement

glucose measurement

alanine measurement

type 2 diabetes mellitus

tyrosine measurement

serum albumin amount

leucine measurement

glycine measurement

Drugs used in diabetes use measurement

blood glucose amount

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