rs798497

This is a intron variant variant in the GNA12 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele G

OR 0.06

p 3.0e-129

N 455,180

Large GWAS

Hispanic or Latin American

Wood AR et al. “Defining the role of common variation in the genomic and biological architecture of adult human height.” Nature Genetics 46(11):1173-86 (2014)

Allele G

OR 0.06

p 2.0e-71

N 253,288

Large GWAS

European

Fernández-Rhodes L et al. “Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.” Hgg Advances 3(2):100099 (2022)

Allele G

OR 0.04

p 8.0e-12

N 59,771

Major Consortium StudyLarge GWAS

Hispanic or Latin American

hip geometry

Faber BG et al. “The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.” Human Molecular Genetics 34(3):207-217 (2025)

Allele A

OR 0.06

p 3.0e-16

N 43,485

Large GWAS

multi-ancestry

BMI-adjusted hip circumference

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)

Allele A

OR 0.03

p 1.0e-10

N 143,480

Large GWAS

multi-ancestry

About GNA12

Enables G protein activity; protein phosphatase 2A binding activity; and protein phosphatase activator activity. Involved in Rho-activating G protein-coupled receptor signaling pathway; regulation of TOR signaling; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in lateral plasma membrane; neuron projection; and neuronal cell body. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

rs798497

GWAS Catalog Trait Associations (3)

body height

hip geometry

BMI-adjusted hip circumference

About GNA12

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